Tolfidine Tolfenamic acid is a particularly powerful NSAID which belongs to the phenamate family.
Tolfine® is a solution for injection based on tolfenamic acid developed by Vétoquinol.
Aagainst many diseases in both cat and dogs: respiratory disorders, mastitis, MMA syndrome, arthritis, omphalectomy,... Its kinetics (entero-hepatic cycle) after intramuscular injection (2 mg/kg: 5 ml/100 kg) make it effective for at least 48 hours after intramuscular injection.
For particularly acute infections, intravenous administration is preferred as it has a more powerful effect. It can be repeated at 24 hour intervals (2 mg/kg: 5 ml/100 kg) or given as a single injection (4 mg/kg: 10 m/100 kg). -
A powerful substance : after analysing existing substances, a powerful, analgesic, antipyretic, anti-inflammatory agent was chosen: tolfenamic acid.
This substance, whose anti-migraine properties are well known to doctors, was developed specifically for dogs and cats. The anti-inflammatory, analgesic and antipyretic potential of Tolfedine® was exploited in the form of tablets and a solution for injection. The range is adjusted to the animal’s weight as there are twodoses: 6, and 60 mg.
These doses mean that animals can be easily treated in divisions of 1.5 or 15 kg of weight. - Fast-acting : being fast-acting, Tolfedine® is one of the leading NSAIDs for all acute indications. S
witching from oral forms to solutions for injection ensures that it can be easily administered by the veterinarian at the consultation or during the animal’s hospitalisation. - Well tolerated : with regard to chronic indications, Tolfedine® has proved to be completely effective and well tolerated in day-to-day veterinary practice and in numerous long-term trials. This tolerance has been confirmed by very favourable pharmacovigilance reports over the years.
Tests back up the results which have been obtained in practice by a cox 2/cox 1 selectivity ratio of 15. Elimination is not altered when the animal has renal insufficiency, nor does the dose have to be adjusted for older animals, which is a guarantee of greater safety: 4 mg per kilogram per day for all ages! - Treating pain during surgery : some operations are known to be particularly painful: osteotomy, head surgery, ovariectomy, etc..
A recent study shows that administering Tolfedine® before surgery considerably increases the animal’s comfort and, as a result, improves the animal’s return to consciousness from anaesthetics and the quality of its convalescence. -
A licence for marketing the drug for dogs and cats : the veterinarian can legally prescribe Tolfedine® because of the licence applying to dogs and cats, proving that it is extremely safe to use on two species whose metabolisms react differently to some NSAIDs.